Emerging Worlds: Chronic Illness and Viral Infections












   
Hemex: A Study Protocol
© Copyright 2001 by Bruce H. Shelton, M.D., M.D. (h), DiHOM, USAPresident of Society of Homotoxicology for North America (SOHNA) and Heel Medical Director
(Explore Issue: Volume 10, Number 5)


We recently had the privilege of visiting with the owners of Hemex Labs of Phoenix, Arizona, Mr. and Mrs. David Berg. Mr. Berg has an MS in Laboratory Science and Mrs. Lois Berg has credentials in the nursing field as it relates to teaching laboratory science. They have done a lot of work in the field of Abnormal Blood Coagulation and the thrust of their work at Hemex is a culmination of nearly thirty years of study in that field. Hemex testing is a complete workup in the nuances of Abnormal Coagulation. This can be mainly a genetically based set of problems or as a set of abnormal terrain abnormalities caused by low-grade infections and environmental toxicity.

A certain small number of our population are very easy "bleeders" as a result of genetic diseases such as Hemophilia. There are the vast majority of people who "clot" their blood normally and, on the other side of the bell shaped curve, a small number of people who are hypercoagulable or "slow bleeders." The Bergs estimate that as many as 14 million Americans have problems with Hypercoagulation.

   
Negative View? It May Be Brain 'Knob'
By Shankar Vedantam The Washington Post
Seattle Times Tuesday, February 12, 2002


A region of the brain a few inches behind the bridge of the nose may hold the key to why some people have a negative outlook on life, scientists said yesterday.

The study, published yesterday in the Proceedings of the National Academy of Sciences, is the first to examine the neurological roots of what scientists call "negative affect," a trait that predisposes people to anxiety, irritability, anger and a range of other unpleasant moods.

By suggesting that an unconscious disposition toward these emotions may be molded by a specific area in the brain, the research moves into previously uncharted waters. It is part of a broad effort by neuroscientists in recent years to use powerful brain-imaging technology to pinpoint the areas of the brain responsible for various emotions.

   
Autoimmune or Viral Disease? Consider Vaccine Contamination
by Dr. Joseph Mercola
Optimal Wellness Center


Chronic Fatigue, Fibromyalgia, Arthritis, Asthma, Lupus, Lymes, Depression, Colitis and Diabetes. Chances are good that you, or some one in your family may be suffering from one of these diseases. The incidence of chronic and degenerative disorders has been steadily on the increase in this country over the last several decades. Our society has been somewhat complacent, accepting these conditions as the inevitable consequence of progress and the resulting pollution of our environment.

"Clinical Management" has taken priority in efforts to treat these diseases, with little or no importance placed on finding the cause. Instead, medical Specialists have segregated various groups of symptoms into a wide array of seemingly distinct clinical entities. Each becoming a separate disease and the exclusive territory of the specialist that treats it. There has been growing evidence, however, in the last number of years implicating chronic viral infections as a root cause for many neuropsychiatric and inflammatory diseases. This evidence however continues to be viewed an “unconvincing” by the Center for Disease Control.

   
Anthrax and Smallpox 101
by Jason S. Kendler, MD; Weill Cornell Medical College of Cornell University, New York
Healthology Press Center For Disease Control


In the days since the Sept. 11 terrorist attacks, countless worried patients have called to ask their doctors about protecting themselves from possible follow up attacks with biological weapons. Many hope to take vaccines for smallpox and anthrax.

One doctor was upset to learn that a patient could not fill a prescription for an antibiotic commonly used to treat a wide range of illnesses. The local pharmacy had run out because the antibiotic is also used to treat anthrax.

Some advice from the doctor:Do not make an appointment to see your doctor for smallpox and anthrax vaccines — they are not available to civilians at this time. And hoarding antibiotics for anthrax will only have the effect of depleting the supply for patients who need them for more immediate reasons.

Since most patients have voiced concern about anthrax and smallpox, below are some details about those two diseases.

   
An Invisible Arsenal-Biological Terrorism
The Seattle Times
Saturday October 6, 2001


Biological Terrorism

Despite federal preparations, many medical experts say the U.S. health system is ill equipped to manage the fallout from a large-scale bioterrorist attack. But the threats are clear. Five biological agents have been given high priority because of their risks to national security.

Press Go to see detailed information with Background, Transmission, Symptoms, Vaccine, Treatment, and Other Information.

   
Beware:Toxic Mold
BY ANITA HAMILTON
Sunday, Jun. 24, 2001


Is the fungus in your floorboards making you sick? With no clear answers, panic and lawsuits abound

Sharyn Iler, 52, of the Woodlands, Texas, an upscale suburb of Houston, couldn't figure out what was wrong. Every time she went into her bathroom to put on makeup, her eyes started burning. She felt constantly exhausted, her vision was blurry and she had a dry cough that just wouldn't quit. Diagnosed with breast cancer in 1998, Iler feared the worst. Perhaps after two years of remission, the disease had returned. She never imagined that the source of her troubles might lie buried within the walls of her $300,000 home--or that she and her husband Bruce would be forced to flee for health reasons with nothing but their dog and cat in tow.

Yet that is exactly what happened one ill-fated afternoon last February. Inspectors had found a thick black mold growing between the stucco and the drywall of the master bedroom, bath, study and dining room. After some of it was identified as stachybotrys atra--a fungus that has been linked to everything from sinus infections to brain damage--an industrial hygienist warned the Ilers to evacuate. Thirty minutes later, they abandoned their home forever. "I thought, This can't be happening to me," says Sharyn. "This is my sanctuary. This is where I come when everything else is wrong."

   
Can He Find A Cure?
Author: Geoffrey Cowley
Newsweek: Special Report: U.S. Edition: June 11, 2001


A vaccine is our last, best hope of stopping the epidemic. Seth Berkley is trying to deliver the dream.

$232,000,000 - The number of dollars the National Institutes of Health spent on research for an AIDS vaccine, up from $82 million in 1993. In 2000, the NIH spent $570 million on new drug therapies, up from $430 million in 1993. There was a time in the early '80s when AIDS was killing people with brutal efficiency, and no one knew what caused it. Was it swine-flu virus? The inhalants that gay men were using to heighten sexual pleasure? There was no telling who would be stricken next, or what it would take to stop the new scourge. But as soon as researchers identified the AIDS virus in 1984, the ultimate solution seemed obvious. Science would vanquish AIDS just as it had polio, measles and smallpox: by immunizing people against it. In announcing the isolation of HIV, federal health officials famously predicted that a vaccine would enter clinical trials within two years and reach the market within three. Seventeen years later experts still agree that a vaccine is our best hope of ending the pandemic. They also agree that we'll be lucky to have even a crude one on the market by 2007. At current rates, an additional 50 million to 100 million people will have contracted the virus by then--most of them in countries too poor to provide treatment--and millions will have died.

   
AUTISM
Michael J. Goldberg, M.D., F.A.A.P.
April 6, 2000


Gentlemen,

I am Dr. Michael Goldberg, a Fellow of the American Academy of Pediatrics and Director of the non-profit NIDS Medical Board and Research Institute. I wish to thank all of you for giving me the opportunity to speak here today and for taking the time to examine the urgency of this epidemic.

I have put together a packet of articles detailing my scientific hypothesis and current treatment philosophy. I suggest they be included in the record. I have also provided information on the emerging science and technology describing Neuro Immune Dysfunction whose common pathway is involved in many immune or autoimmune diseases including the development of the Autistic Syndrome. We finally have an understanding of how the brain interrelates with the endocrine and immune system. We are confident that we can apply this new understanding rapidly to evolve a treatment plan within the next six to twelve months, through an unprecedented blend of private enterprise and government-supported research.

   
Scientists Discover How Some Viruses Take Strong Hold of Cells
Brookhaven National Laboratory
September 25, 2001


UPTON, NY -- As part of an ongoing effort to understand how viruses infect cells, scientists at the U.S. Department of Energy's Brookhaven National Laboratory have deciphered the molecular-level interaction between coxsackievirus -- which infects the heart, brain, pancreas, and other organs -- and the human cell protein to which it attaches.

This work, published in the October issue of Nature Structural Biology, may lead to improved ways to thwart viral infections, and may help scientists design virus-based vehicles for gene therapy. The study reveals that the receptor protein for coxsackievirus (known as coxsackievirus-adenovirus receptor, or CAR) forms pairs on the surface of human cells, with two adjacent CAR receptors attached to one another below the surface of the cell membrane. When coxsackievirus binds to the human cell, it forms bonds with both receptors of the pair.

   
Cervical Cancer Test
Dr. Kim Mulvihill
Tuesday, February 20, 2001


Each year almost 13,000 American women are diagnosed with cervical cancer, and 4,400 die from the disease. Now a new test could help us identify sooner which women are most at risk of the disease. Now a study in the Journal of the National Cancer Institute says testing for the Human Papilloma Virus or HPV could provide the clues we need. Researchers at the National Institutes of Health followed more than 3,000 women with abnormal Pap smears

   
Children Exposed to Chemicals at School
Reuters, March 19, 2001


An increasing number of U.S. schools are built on abandoned dump sites or too close to polluted factories and pesticide spraying at schools could be contributing to diseases in children from asthma to testicular cancer, an environmental group said Monday.

   
Questions and Answers: The Nature of Disease
Interview with Dr. Ian Lipkin
Newsweek


Are infectious agents responsible for more diseases than we currently realize?

July 7 — A recent study by German researchers reportedly found that the Borna virus, an infection that is known to cause behavioral changes in some animals, was present in up to 100 percent of people experiencing severe mood disorders, but in only 30 percent of people who were healthy. The results prompted new speculation as to whether or not the Borna virus causes depression.

Neuroscientist Dr. Ian Lipkin, director of the Emerging Diseases Laboratory at the University of California, Irvine, is not convinced that the link between the two has been proven. Still, Lipkin does believe that infections may be at least in part responsible for the development of many diseases. NEWSWEEK’s Laura Fording asked Lipkin, who will soon be moving to the Mailman School of Public Health at Columbia University, to elaborate.

   
Brain Fog: Has Lyme Disease Affected Your Child?
Joel Cohen, Medical Writer
CBS HealthWatch - Feb.2001


Does Lyme disease turn "A" students into failing students? Can it render athletic kids wheelchair-bound or transform happy children into suicidal children?

This puzzling infection has been called "the new great imitator" (syphilis was the previous great imitator) because it causes vague, flu-like symptoms and a circular rash that is easy to miss. Lyme disease can both look like and lead to learning disabilities, mood disturbances, depression, anxiety, attention deficit disorder, and even manic or psychotic behavior.

Researchers aren't certain how frequently Borrelia burgdorferi - -the corkscrew-shaped bacteria that causes Lyme disease--attacks the brain or nervous system. Dr. Brian Fallon, an associate professor of clinical psychiatry atColumbia University and director of its Lyme Disease Research Program, estimates that if diagnosed and treated early, less than 5% of sufferers will develop brain or nerve complications--a condition known as neuroborreliosis. If leftundiagnosed and untreated, the Lyme bacterium may attack the brain or nerves in as many as 40-50% of patients.

   
Surgeon General on Children's Mental Health

National Institute of Mental Health


According to a press release from the U.S. Department of Health and Human Services, on January 3, David Satcher, M.D., Ph.D., Assistant Secretary for Health and Surgeon General, released the "Report of the Surgeon General's Conference on Children's Mental Health: A National Action Agenda," which outlines goals and strategies to improve services for children and adolescents with mental health problems and their families. According to the Report, the Nation is facing a public crisis in mental health for children and adolescents.

   
Encephalitis led to Alaska Airlines Attack
By Kim Curtis
The Associated Press


SAN FRANCISCO - A hulking passenger who broke into the cockpit of an Alaska Airlines plane and lunged for the controls in March was suffering a rare reaction to encephalitis, lawyers on both sides agreed.

Prosecutors and the attorney for Peter Bradley, 39, were working yesterday on a plea bargain.

Bradley has no memory of the attack, and experts needed weeks to unravel the mystery, according to his attorney, Jerrold Ladar. They concluded that encephalitis - an inflammation of the brain - had made him delirious.

   
Doctors Warned of H.I.V. Drug Risks in Pregnancy
By REUTERS
New York Times, Thursday, February 2, 2001


Doctors throughout Europe are being warned of a potentially fatal side effect if pregnant women infected with HIV take Bristol-Myers Squibb's AIDS drugs Zerit (stavudine and Videx(didanosine).

   
Rock-tosser sentenced in teen's meningitis death
Seattle Times
Nation & World : Saturday, April 14, 2001


JOPLIN, Mo. - A man was sentenced to seven years in prison for involuntary manslaughter yesterday in the death of a teenage girl who contracted meningitis from a rock he tossed through her windshield.

Joey Virgo, 21, had pleaded guilty in the death of 17-year-old LeAnne Hamm. Virgo threw a rock that caused the car to run off the road in August 1998. He said the girls had been annoying him by speeding by his house. Hamm fell ill in October 1998 and died two months later. A forensic specialist testified that an organism that was in the dirt on the rock had made its way into Hamm's brain.

   
Coconut Oil Could Check the Aids Virus
Journal Of Medical Sciences
Chennai, August 3, 2001


Coconut oil, often blamed by the medical community as a high cholesterol agent causing coronary problems, may turn out to be the saviour for millions of victims of the dreaded AIDS virus. Jon J Kabara, professor emeritus, Michigan State University and Dr. Conrado S Dayrit, emeritus professor of pharmacology, University of the Philippines say that preliminary studies conducted in the US and Philippines have shown that the use of coconut oil or coconut could effectively check the proliferation of HIV virus. In separate presentations during the International Coconut Conference –2000 held in Chennai recently, Kabara and Dayrit said high presence of lauric acid in monoglyceride form known as monolaurin in coconut and coconut oil provides them with the anti-viral quality. According to the two scholars monolaurin present in coconut and its oil could be rated as one of the best natural anti-viral agents. According to Kabara over 20 clinics in USA are now investigating the use of monolaurin in checking various viral diseases including HIV and hepatitis-C infections.

   
Doctors try to determine if woman is first 'mad-cow' victim in U.S.
by Shankar Vedantam
Knight Ridder Newspapers - March 24, 2001


PHILADELPHIA - Evelyn Mahan remembers the last conversation she had with her daughter Carrie. As goodbyes go, it wasn't much.

It was a Sunday night. Carrie, 29, who was working two jobs and studying for a second bachelor's degree in accounting, called from her home in Philadelphia to say she'd been to a party in New York with her boyfriend. She had been tired before she left and was tired now. That was it.

On Monday, Carrie told her boyfriend she didn't feel well. He took her to an emergency room. Doctors gave her medicine. She slept poorly and was back in the ER the next day.

Her chief complaint was nausea. But the symptoms soon worsened: Carrie began hearing music in her head. She hallucinated. She felt acutely afraid. Within days, she was in a hospital psychiatric ward.

In the six weeks that followed, doctors puzzled over Carrie's strange symptoms. As her family clamored for answers, doctors raced packages of her brain tissue across the country to top scientists.

   
Bacteria More Resistant To Antibiotics, Study Says

Washington Post


One of nature's most common -- and dangerous -- disease-causing bacteria is developing antibiotic-resistant strains at an increasing rate, the latest evidence that overuse of "wonder drugs" is causing them to lose their effectiveness.

A report in today's issue of the New England Journal of Medicine found that the rate of multidrug resistance for the microbe Streptococcus pneumoniae had increased from 9 percent to 14

   
vCJD and BSE - the link
BBC-News-Friday, 20 October, 2000, 16:44 GMT 17:44 UK


vCJD,Creutzfeldt-Jacob disease, is the human form of mad cow disease, an untreatable and invariably fatal disease in humans which is similar to BSE in cattle and scrapie in sheep. The diseases are together called "spongiform encephalopathies", because they all reduce the brain to the same spongy appearance, with gaps appearing within the tissue.

   
The Gut-Brain Axis in Autism
Dr. Andrew Wakefield
At The International Symposium on Autism 28 December 1999


The tact is going to change considerably now to a subject which I understand a little bit about - that is, gastroeterology. I'm a gastroeterologist. I'm obliged to say at the outset that the data that I'm going to present today, represent my opinions and those of my colleagues and are in no way associated with the institution from which I come. Having said that, over the past 10 years, my group has been involved in the investigation of inflammatory bowel disease, i.e, Crohn's Disease, etc. Through our investigation of that, we came to study autism, which may sound a somewhat circuitous route.

What I'm going to try to persuade you on today is that we can bring at least some new insights to a sub-group of autistic children, those with bowel symptoms and to suggest to you that at least autism in this group may have at its core origin a primary problem in the gut, rather than a primary problem in the central nervous system. It is the central nervous system that is affected as a consequence of that gut damage. It's up to you at the end to decide to what extend this applies to your child or the children that you treat or teach because, clearly, it is a sub-group of the autistic population. We've presented a paper in the Lancet two years ago on 12 children who came to us with 'regressive autism'. This is the key phenotype that we've been looking at - that is, children who are normal for the first year to 18 months of life and then regress either dramatically or over a period of months. This is associated with the change in their bowels.

   
Can The US Prevent a 'Mad Cow Outbreak?'
Nell Boyce
Science & Ideas 1/29/01 US News and World Report


"The greatest risks for Americans - in addition to a tainted blood supply - come from vaccines and from dietary supplements that are made from bovine materials from Europe." As expert testimony before a government hearing indicated last week, Americans should not become too complacent. If that cheeseburger poses little risk, blood trans- fusions may. Indeed, the expert panel warned that the nation needs to do a better job of protecting the purity of its blood supply–some of which actually comes from Europe.

   
NEW THEORY EMERGES ON FATIGUE AILMENT
The Wall Street Journal
AP- Toronto Tuesday, Sept. 19, 2000


-- Viruses that insidiously damage heart muscle may be the cause of chronic fatigue syndrome, a mysterious malady that many physicians have written off as a psychological condition, according to a provocative new study by an infectious disease expert. At a major scientific conference here, Martin Lerner, a doctor at William Beaumont Hospital in Royal Oaks, Michigan, presented data on a series of patients, including himself, who developed the debilitating condition and were later treated, with apparent success, with potent antiviral drug regimens.

   
Chronic Illness Gives Life a Sharper Focus
JUDY FOREMAN
Special to The Times, Monday, February 19, 2001


At 68, Helen Freeman has more chronic diseases than many of us will face in a lifetime. First, there's the fact that she has great trouble breathing, even at sea level in Seattle, where she lives, because of extensive scarring from years of lung infections.Then there's the diabetes, for which she needs daily medication. The glaucoma is no picnic, either—she's almost blind in one eye. She's also had melanoma and breast cancer.

   
Mysterious Syndromes Studied
By LIND A. JOHNSON Associated Press Writer
February 4, 2001 LA times


Numerous illnesses for which doctors can find no cause -or even conclude it's all in the patient's head -probably are caused by multiple physical, psychological and social factors interacting in complex ways not yet understood, scientists said at a recent conference at Rutgers University.

   
Collection of Mad Cow Articles in the US from 2000
Various


The quarantine of 1,221 cattle and recall of 22 tons of feed out of fears about mad cow disease may have been caused by a mill that disclosed a possible rule violation. A Purina Mills Inc. plant may have mixed cow meat and bone meal into a feed supplement that was put on the wrong truck, said Beverly Boyd, spokeswoman for the Texas Department of Agriculture. A Purina Mills spokesman said Friday the company had begun phasing out the use of meat and bone meal from cows in any of its livestock feed. Beef byproducts are banned for cattle or sheep feed but commonly used in swine and poultry feed. ``This (quarantine) just happened to be a matter of timing. But as of last night, we are no longer using it,'' said Max Fisher, a spokesman for St. Louis-based Purina Mills, the nation's largest maker of livestock feed. ``It's a voluntary move on our behalf and takes us down to a zero risk factor for a misformulation in the future.''

   
GULF WAR TESTIMONY OF HOWARD B. URNOVITZ, PH.D.
HOWARD B. URNOVITZ, PH.D.
FEBRUARY 2, 2000 U.S. HOUSE OF REPRESENTATIVES COMMITTEE ON GOVERNMENT REFORM


I am grateful to the Committee for allowing me the opportunity to review the GAO report on Gulf War Illnesses: Management Actions Needed to Answer Basic Research Questions and for inviting me to present my views and recommendations on research directions for Persian Gulf War Related Illnesses or GWS, Gulf War Syndrome. My name is Dr. Howard B. Urnovitz. I received my doctorate degree in Microbiology and Immunology from the University of Michigan in 1979. My entire CV is submitted with my written testimony. I currently hold the position of Scientific Director of the Chronic Illness Research Foundation as well as my current position as Chief Science Officer and Director of a publicly traded biomedical company

   
Studies Find More Heart Disease,Infection Links
Reuters
November 7, 2000


WASHINGTON-Three studies to be published on Tuesday strengthen theories that infections may be linked with heart disease in some cases. It was shown to be common that people with heart disease were infected with herpes simplex, cytomegalovirus,and Chlamydia pneumonia.

   
Mold Infestation Threatens Homes
By BRIAN WITTE, Associated Press Writer BELCOURT, N.D.
Associated Press Sun, Aug 19, 2001


Lowella Allard no longer goes into her basement, where mold grips the walls and the damp, thick air is hard to breathe. Mold, she says, festers inside the insulation and is the reason behind her dry cough and frequent headaches. "I go through Tylenol like crazy and I just don't get any better," Allard said during a tour of her home by officials from the Federal Emergency Management Agency, the Indian Health Service and the Bureau of Indian Affairs.

Some 320 federally subsidized homes on the Turtle Mountain Indian Reservation are infested with mold. Residents say the infestation is sickening, and tribal officials say at least seven deaths in recent years could be related to the infestation, which is so pervasive they estimate 210 homes will have to be destroyed.

   
Hope for AIDS cure fades
By Daniel Q. Haney
The Associated Press


Will AIDS ever be cured?

The most recent research on the resourceful virus that causes the disease suggests a disheartening answer: probably not.

A few years ago, even some of the most sober-minded researchers wondered if the end of AIDS might be near. Perhaps the pills that miraculously changed the human immunodeficiency virus (HIV) from a death sentence to a chronic infection would go the final step, they thought, eventually purging every trace of the virus from the human body.

Such talk quickly faded. The new drug cocktails, amazing as they were, could not get rid of the virus. Even if all signs of it vanished for years, HIV was lurking. Inevitably it roared back by the billions as soon as people stopped taking their medicines.

Ever since that realization sank in, finding HIV's hiding places has been the goal of a small group of researchers. What they have learned is one of the biggest disappointments in AIDS research.

   
Cannibalism's clues to CJD

BBC News Friday, 23 March, 2001, 12:18 GMT


Nobody knows how many will be killed by the human form of mad cow disease. But a similar disorder among cannibals in Papua New Guinea gives some important clues. Ever since a link was established between mad cow disease and its human form, variant CJD, a time bomb has been ticking. Because the fatal vCJD takes years to emerge in humans, the number of new cases is rising all the time But experts are stumped when it comes to estimating the total number of deaths. Suggestions have ranged from millions to a few hundred.

   
More Than 1 Million Chickens To Be Killed To Battle Virus
Seattle Times Nation & World
Saturday, May 19, 2001


HONG KONG - The Hong Kong government yesterday ordered the immediate slaughter of 1.2 million chickens - virtually the territory's entire poultry population - in a drastic attempt to stamp out a killer virus that officials fear could eventually affect humans.

   
The Effects of Coconut Oil On HDL'S and Cholesterol
MARY ENIG Ph.D.
Report 14, Keep Hope Alive


Dr. Mary Enig MS (Nutritional Sciences), Ph.D. did original research that showed a positive link between vegetable oil and cancer and a negative correlation for animal fat. She originated comprehensive analysis of trans fatty acid components of over 200 foods. Trans fatty acids are formed when vegetable oils are hydrogenated or heated to high temperatures. With high temperatures, trans fatty acids are fats that are twisted, which alter their natural “cis” shape. She studied how the trans fatty acids from foods affected the liver’s mixed function oxidase enzyme system that metabolizes drugs and environmental pollutants in the body. An important finding of this latter study was that laboratory animals fed experimental diets containing trans fatty acids have altered activity of this enzyme system. These results were partly responsible for the review of the “Health Aspects of Dietary Trans Fatty Acids” held by the Federation of American Societies for Experimental Biology, Life Sciences Research Office, at the request of the Food and Drug Administration. Mary Enig has had 17 articles published in scientific journals since 1976. In 1986,she was appointed by the Governor of Maryland to the “State Advisory Council on Nutrition.” She was contributing editor to “Clinical Nutrition” magazine and consulting editor for the “Journal of the American College of Nutrition.” She has given over 50 seminars and lectures on since 1979 on foods and nutrition topics.

   
What Causes Chronic Fatigue Syndrome?
(Online) www.well-connected.com
June 1999.


A good distillation of the theories about chronic fatigue syndrome's possible causes. Theories abound about the causes of chronic fatigue syndrome. Many physicians still doubt that CFS is an actual disease but believe rather that it is a component of a psychological disorder or a symptom of other problems, similar to anemia and high blood pressure. Indeed, no primary cause has been found that explains all cases of CFS, and a number of experts believe that it develops from a combination of factors including brain abnormalities, a hyper-reactive immune system, and a viral or other infectious agent. Still, although all of these elements appear to be at work in many cases of CFS, it is not yet clear what sequence of events actually leads to the fatigue and other prominent symptoms of this disorder. Other conditions that have been posited as causes for certain CFS cases include hypotension, hyperventilation, and defective muscle tissue.